For example, PLG is a partner to rs3127573 in the kidney, while in non-renal GTEx tissues, this variant is associated with the expression of SLC22A3. Another CKD-dt GWAS eSNP (rs9275424) was associated with the same eGene (HLA-DRB1) in the kidney and GTEx tissues but the direction of this association was different between renal and non-renal tissues. The gene discussed is SLC22A3; the disease is chronic kidney disease.