Indeed, analysis of Cancer Cell Line Encyclopedia confirmed that Ets1 expression was negatively correlated with Dnmt3a (Spearman r = −0.4139, **p = 0.0011) and Dnmt3b (Spearman r = −0.5878, ***p < 0.0001) but positively with Apobec3c (Spearman r = 0.6239, ***p < 0.0001) (Fig. 4f). Here, ETS1 is linked to cancer.