Binding of NFATc2 and NFKB1/RELA heterodimer to the CRE region synergistically contribute to the expression of Ets1. NFATs and NF-κBs factors are reported as downstream targets of calcium and PKC signaling, respectively, and affect expression level of their target genes associated with tumor pathogenesis42–47. The gene discussed is PRRT2; the disease is neoplasm.