A recent work by Cordero-Reyes et al. [50] used SCID mice (i.e., lacking B and T cells), mice treated with anti-CD22 (i.e., CD22 mice lacking B cells), and nude mice (i.e., lacking T cells) in an ATII infusion PO-HF murine model to evaluate the separate roles of the lymphocytes. The gene discussed is CD22; the disease is hydrops fetalis.