PARP1 and posterior cortical atrophy: Importantly, the transcripts associated with active PARP‐1 (down‐regulated by PARPi) in both HT‐sensitive and CRPC cells significantly increased in expression from benign tissues, to primary PCa, to PCa metastases (Fig 2C) when these transcripts were queried against a publically available data set (Grasso et al, 2012).