PARP1 and posterior cortical atrophy: Dual assessment of DSB repair and PARP‐1 activity in each specimen revealed a positive correlation between PAR and γH2AX in non‐neoplastic prostate tissues (r = 0.2853), and primary PCa tissues (r = 0.3573), but this association is lacking in mCRPC tissues (r = −0.03825; Fig 1E), further indicating that elevated PARP‐1 enzymatic function in mCRPC is not attributable to increased DNA DSB repair.