Given the potential implications of PARP‐1‐mediated functions in human malignancies, and the need for biomarkers of PARPi response, it was imperative to discern the molecular basis of PARP‐1 function and activity in the context of BRCA1/2 wild‐type PCa, and determine the contribution of PARP‐1‐mediated transcriptional events on tumor phenotypes. The gene discussed is BRCA1; the disease is posterior cortical atrophy.