PARP1 and posterior cortical atrophy: To assess PARP‐1‐mediated transcriptional regulation in the context of androgen signaling, hormone therapy‐sensitive (HT‐sensitive) PCa cells were deprived of steroids for 72 h, then treated with PARP‐1 inhibition (or control) followed by 16 h dihydrotestosterone (DHT) stimulation as depicted in Fig 2A (left) to assess the impact of PARP‐1 suppression in the presence and absence of AR activity.