PARP1 and neoplasm: While data presented in Fig 1F indicate that the correlation between DSBs and PARP activity is loss during disease progression, data in Fig 7B demonstrate that artificially de‐coupling PARP‐1 transcriptional regulation of DNA repair factors renders tumor cells unresponsive to PARP inhibition, thus demonstrating that transcriptional regulation of DNA repair factors by PARP‐1 has an impact on both the biochemical and the biological response to PARPi.