E2F1 and neoplasm: Furthermore, it was determined that PARPi alters the activation status the endogenous inhibitor of E2F1 function, the retinoblastoma tumor suppressor (RB; Fig 5F), wherein PARPi resulted in enrichment of hypophosphorylated (active) RB, suggesting that the functions of PARP‐1 suppression may be pleiotropic.