Given the potential implications of PARP‐1‐mediated functions in human malignancies, and the need for biomarkers of PARPi response, it was imperative to discern the molecular basis of PARP‐1 function and activity in the context of BRCA1/2 wild‐type PCa, and determine the contribution of PARP‐1‐mediated transcriptional events on tumor phenotypes. This evidence concerns the gene PARP1 and posterior cortical atrophy.