PARP1 and posterior cortical atrophy: These data indicate that there may be a core transcriptional program regulated by PARP‐1 in PCa cells, which includes a large number of DHT‐responsive genes (n = 169), but the transition to castration resistance likely expands the relevance of PARP‐1‐regulated transcription, given the larger number of transcripts that are altered upon PARPi (n = 1,810 unique genes regulated by PARP‐1).