PARP1 and posterior cortical atrophy: Initially, human tissues from primary, hormone therapy (HT)‐sensitive PCa, and metastatic CRPC (mCRPC) were queried for PARP‐1 enzymatic activity via immunohistochemistry (IHC) for PAR (Poly(ADP‐ribose), the product of PARP‐1 enzymatic activity; Fig 1A).