PARP1 and posterior cortical atrophy: This analysis indicated that PARP‐1 enzymatic activity as a function of disease progression was not associated with repair of DSBs (Fig 1D, bottom right; median values 44.20, 51.80, and 46.20 for non‐neoplastic, primary PCa, and mCRPC, respectively), suggesting that PARP‐1 activity is regulated by other factors in addition to DNA damage.