HLA-C and neoplasm: Substantial preclinical and clinical investigations have elucidated the favorable conditions for immunotherapy, namely: a tumor cell’s ability to properly present, or release, immunogenic antigens; an abundant neoantigen repertoire; a robust and uninhibited T-lymphocyte infiltrate; and a tumor and stromal microenvironment that permits the infiltration and functionality of effector T cells; so that activated tumor-specific T cells can identify tumor cells in the context of major histocompatibility complex (MHC)-peptide complexes and induce tumoricidal cytolysis.