MAPT and Alzheimer disease: Relative to age-matched controls, mice fed with HFD for 16 weeks showed a ubiquitously increased hyperphosphorylation pattern of tau at residues of serine 396 (S396) and 404 (S404), threonine 205 (T205) and 231 (T231), which define AD’s type of phospho-tau [31], primarily in the GCL and IPL of retinae (Fig. 2a; Additional file 1: Figure.