A dynamic test of lactate production (Fig. 1j) confirmed that SOX2 silencing in acidosis-exposed melanoma cells reverted OxPhos to a more glycolytic metabolism, further confirmed by the down-regulation of OxPhos-related enzymes, peroxisome proliferator-activated receptor gamma coactivator 1-α (PGC1α), cytochrome-c (Cyt-c), cytochrome c oxidase subunit 4 isoform 1 (COX4I), cytochrome c oxidase subunit 5B (COX5B), ATP Synthase F1 Subunit Alpha (ATP5A1) (Fig. 1k). The gene discussed is COX5B; the disease is melanoma.