Lowering SOX2 level in melanoma cells, besides causing a decrease in cell proliferation (Additional file 1: Figure S1a) in accordance with the literature [13], correlated with a more glycolytic metabolism, as confirmed by augmented lactate production (Fig. 1h) and the increment of glycolytic gene expression together with a reduction of oxidative ones (Fig. 1i and Additional file 1: Figure S2). This evidence concerns the gene SOX2 and melanoma.