SOX2 and melanoma: To confirm the correlation between SOX2 and OxPhos metabolism and evaluate the occurrence of any metabolic variations, we modulated SOX2 expression in other two human melanoma cell lines, chosen among a panel of cell lines based on their SOX2 expression level: patient-derived SSM2c cells, that express high levels of SOX2, and 501-Mel cells, that express very low SOX2 levels (Fig. 3a).