MMP-9, TIMP-2 and TIMP-1 have been shown to be elevated in patients with severe sepsis and septic shock [16, 17] as well as in animal models of endotoxemia [18], while MMP-1 [19], MMP-8 [20, 21] and MMP-13 [22] have also been associated with sepsis. This evidence concerns the gene MMP1 and Sepsis.