GLP1R and Hyperglycemia: Whilst the glucagon infusion caused a rise in plasma glucose as expected, this rise was blunted in the combined infusion, owing to a significant synergistic effect between GLP‐1 and glucagon on insulin secretion.55 A subsequent study by Cegla et al56 confirmed that the addition of GLP‐1 to glucagon infusion protected from glucagon induced hyperglycaemia, and that co‐infusion of GLP‐1 and glucagon at sub‐anorectic doses led to a significant and synergistic reduction in food intake of 13%.