Apossibly ideal additional criterion is renal biopsy showingimmune-complex-mediated nephritis with complement deposition associated withvarying degrees of cell injury.(30) Renalbiopsy must be ordered whenever LN is suspected.(30) In order to be diagnosed with LN alone, patients must have renalbiopsy findings consistent with LN along with high levels of antinuclearantibodies (ANA) and/or increased circulating levels of anti-double stranded DNA(anti-dsDNA) antibodies.(29). The gene discussed is BTG3; the disease is lobular neoplasia.