Due to the known physiological role of Cav1.3 for brain development and function [2,18] and the recent findings of recurrent de novo germline CACNA1D mutations in patients with neuropsychiatric and neurological symptoms this gene has been incorporated in custom genetic panels for clinical diagnosis, including autism/intellectual disability (Autism/ID Xpanded Panel). The gene discussed is CACNA1D; the disease is Intellectual disability.