TBK1 and Splenomegaly: Interestingly, while type 1 IFN production by dendritic cells themselves was attenuated, the broader interferon response was hyperactive in these animals and appeared to drive much of the phenotype, as crossing CD11c-Cre TBK1 mice to interferon alpha receptor 1 (IFNAR1)-KO mice essentially reversed the splenomegaly, lymphadenopathy and T-cell activation states [161].