Interestingly, the protein levels of all the components of GINS (PSF1, PSF2, PSF3 and SLD5) were decreased when quiescence of glioma cells was induced by hypoxia or serum deprivation and restored again by releasing cells from hypoxia and serum deprivation (Fig. 3e, f). The gene discussed is GINS4; the disease is central nervous system cancer.