ANGPT1 and neoplasm: In general, the over-expression of RAS components within the Ang II/AT1R axis (such as ACE and AT1R) is associated with tumor growth and with more aggressive tumor features in several types of human cancer, including breast cancer, ovarian cancer and renal cancer [17–19], whereas Ang II/AT2R and Ang(1-7)/MasR showed opposite effects [20].