ILIR1 was selectively upregulated in ependymomas, as compared to other common CNS tumors, with highest expression levels in the aggressive ST-EPN-RELA and PF-EPN-A molecular subgroups and showed positive correlation with EMT markers, higher proliferation index, and immunological and angiogenesis related pathways and stemness. The gene discussed is MME; the disease is central nervous system neoplasm.