Supportive of these findings, gene expression analysis of our in-house EPN cohort showed upregulated IL1R1 expression levels in corresponding clinico-pathologic-molecular subgroups (ST-RELA+ and pediatric PF) with significant correlation with higher Snail/Slug expression levels, higher proliferative indices and poorer progression free survival. This evidence concerns the gene IL1R1 and pemphigus foliaceus.