Supportive of these findings, gene expression analysis of our in-house EPN cohort showed upregulated IL1R1 expression levels in corresponding clinico-pathologic-molecular subgroups (ST-RELA+ and pediatric PF) with significant correlation with higher Snail/Slug expression levels, higher proliferative indices and poorer progression free survival. The gene discussed is SNAI2; the disease is pemphigus foliaceus.