Among the 29 patients with a history of VT, five had aPL positivity (LA and/or anti-β2GpI, but no aCL), 2 were diagnosed as having APS (they were both positive for LA, none of them were positive for anti-DNA antibodies or fulfilled systemic lupus erythematosus criteria). The gene discussed is ACLY; the disease is autoimmune polyendocrinopathy.