In multivariate analysis (model adjusted on sex, age, disease subtype, tobacco use, follow-up, gammaglobulin level, and anti-U1RNP positivity), there was an association between aCL titers (≥5 UGPL/mL) and VT (OR 3.69; [0.98–12.9]; p = 0.043) as well as with PAH (OR 6.35; [0.99–41.1]; p = 0.043). The gene discussed is ACLY; the disease is pulmonary arterial hypertension.