Further, forward mode NCX is reduced (Camors et al., 2012), leading to increased CaMKII activity (Popescu et al., 2016) and higher frequency of Ca2+ waves (Camors et al., 2012) in Ankyrin B+/− mice, suggesting that the mechanisms discussed for hypokalemia also partly could explain induction of ventricular arrhythmias in the Ankyrin B syndrome. This evidence concerns the gene CAMK2G and Hypokalemia.