Increased expression and activity of CaMKII are also consistently observed in HF (Hoch et al., 1999; Kirchhefer et al., 1999; Zhang et al., 2003), and contribute to increased intracellular Na+ and Ca2+ by increasing INa−L (Anderson et al., 2011) and Ca2+ leak through RyRs (Ai et al., 2005). The gene discussed is CAMK2G; the disease is hydrops fetalis.