14-3-3 proteins have been shown to interact with wild type LRRK2 and several PD-associated LRRK2 mutants including R1441C, R1441G, R1441H, Y1699C, and I2020T, but not G2019S, which has been shown to disrupt the interaction with 14-3-3 proteins (Dzamko et al., 2010; Nichols et al., 2010; Li et al., 2011). Here, LRRK2 is linked to Parkinson disease.