SPRY2 and familial pancreatic carcinoma: Consistent with the function of Spry2 detected in our study, Spry2 protein expression was low in pancreatic cancer tissues (Fig. 7c), and downregulated Spry2 expression was associated with pathological grade, T stage, N stage and AJCC stage (P < 0.05 for all, Supplementary Table 2 and Fig. 7d).