Compared with non-users, usage of statins prior to admission was not associated with a reduced risk of DHF/DSS on multivariate analysis, after adjusting for potential confounders including age, gender, year of presentation, BMI, CCI, hypertension, and other medications including antiplatelet drugs, ARB, ACEI, insulin, metformin and sulfonylurea. This evidence concerns the gene INS and Hypertension.