In order to identify compounds which were potentially chondroprotective, ninety six diet-derived bioactives were screened at 10 μM against basal and IL-1-induced MMP13 expression (measured by RT-qPCR) in SW1353 human chondrosarcoma and C28/I2 immortalised human costal chondrocytes. The gene discussed is IL1B; the disease is chondrosarcoma.