As AR—the main driver of prostate cancer—functions in conjunction with chromatin modifications to control transcription, we set out to comprehensively profile 100 primary prostate carcinomas by sequencing RNA transcripts in combination with ChIP-sequencing for AR and the active histone marks H3K27ac, H3K4me3 and repressive mark H3K27me3. This evidence concerns the gene AR and Familial prostate cancer.