In contrast, CD27+ B cells showed higher levels of total Caspase-3-activated cells in both CVID patients’ groups compared to controls (Fig. 4e) that nearly statistically correlated with in vitro Bax MFI in CVID CD27+ B cells (Spearman’s R = 0.683, P = 0.0503). Here, BAX is linked to common variable immunodeficiency.