Interestingly, anti-CD40+IL-21 stimulation of CD27– B cells induced normal Bcl-2 levels in both CVID groups and normal levels of Bcl-XL in AP patients (Fig. 7a), contrarily to what happened in anti-CD40-stimulated CD27– B cells (Fig. 5c). This evidence concerns the gene BCL2 and common variable immunodeficiency.