Consistent with our initial predictions, genes upregulated by HEY2GE and downregulated by HEY2OE include NR2F2, the Notch signaling genes (JAG1 and DLL3), regulators of cardiac contractility (MYL3, COX6A1), neurogenesis (INA, BASP1, NEFL), and human atria enriched genes (NR2F2, MYLK, RBP1), while genes with the inverse signature included those enriched in heart ventricles (PDLIM1, VTN, LPL) and cardiac hypertrophy (MYH7, CORIN, TCAP). The gene discussed is NR2F2; the disease is cardiac hypertrophy.