More specifically, GATA3 expression was shown to inhibit breast cancer growth and pulmonary metastasis by repressing metastasis-associated genes such as ID1, ID3, KRTHB1, LY6E and RARRES3 [83], and restoration of Gata3 expression in a breast cancer mouse model induced breast cancer differentiation and supressed its dissemination [82]. This evidence concerns the gene PLAAT4 and breast cancer.