IL6 and polycystic ovary syndrome: Here, we demonstrated that the estrous cycle of PCOS rats was disordered, and IL-6 expression was significantly increased in ovarian tissues of PCOS rats, total flavonoids could recover estrous cycle and decrease the level of IL-6 that increased in PCOS rats, indicating that total flavonoids might treat PCOS through down-regulating the IL-6 expression and promoting the recovery of ovarian function.