The most common ASD associated syndromes include: i) Fragile X syndrome (caused by expansion of polymorphic CGG repeat upstream of the FMR1 gene) in which over 40% show Autism core symptoms; ii) Angelman syndrome, determined by a deletion of 15q11–13 where ASD is present in about 50% of cases; iii) Tuberous Sclerosis, due to mutations in two functionally-related genes, TSC1 and TSC2, in which autism is present in more than 60% cases; iv) 22q deletion (or Phelan-McDermid) syndrome where about 80% of cases present with autistic symptoms [16]. The gene discussed is TSC2; the disease is autism.