At day 3 post-injection, Ins2Akita mice experienced similarly altered expression of genes associated with retinal inflammation and neurovascular tissue remodeling in response to diabetes-related stressors compared to age-matched WT mice (Ch25h: 4.2 ± 0.7, Crybb2: 7.1 ± 2.6, Edn2: 2.3 ± 0.6, Gbp2: 1.3 ± 0.2, Icam1: 1.4 ± 0.2, Lgals9: 2.3 ± 0.4, Lama5: 1.4 ± 0.1, Serping: 2.2 ± 0.2, Timp1: 3.2 ± 0.7 as compared to WT mice: 1 ± 0.0, p < 0.05). Here, EDN2 is linked to diabetes mellitus.