This apparent difference between ASCs and ASC-CM was also observed in retinal gene expression changes observed in this model, specifically, genes coding for proteins involved in infection and immune responses (Gbp2; Lgals9; Ch25h) and in intracellular signal transduction pathways activated by cytokines and chemokines, such as adhesion and tissue structure (Icam-1; Lama5), inflammation (Ccl2; Edn2; CD11b), and protein degradation (Timp1). Here, EDN2 is linked to infection.