AFP and neoplasm: Patients with low rad-score were positively associated with high preoperative alpha-fetoprotein (AFP) level (p < 0.001), larger tumor size (p < 0.001), presence of vascular invasion (p = 0.009), advanced TNM stage (p = 0.015) and BCLC stage (p = 0.020), suggesting that low rad-score may indicate tumor aggressiveness.