SOCS1 and diffuse large B-cell lymphoma: In addition, an enrichment for SOCS1 and PIM1 mutations in matched tumor samples was not only observed in R/R DLBCL (4 out of 7 patients), but also in transformed FL (4 out of 7 patients), as well as in relapsed FL (2 out of 7 patients), further supporting the role of mutations in these genes in relation to relapse [38].