The knockdown of YAP in dermal fibroblasts attenuated the TGF-β-mediated formation of contractile actin stress fibers and the deposition of collagen type I. In addition, YAP/TAZ proteins were localized in the nucleus of fibroblasts in skin biopsies from patients with systemic sclerosis (SSc) [49]. The gene discussed is TGFB1; the disease is systemic sclerosis.