In prostate cancer cells, ECM-deposited latent TGFβ can be activated by membrane type I-matrix metalloprotease (MT1-MMP/MMP14), which then induces the secretion of Wnt5a; the sequential action of TGFβ and Wnt5a sustain EMT and invasiveness of the tumor cells [31]. This evidence concerns the gene WNT5A and prostate cancer.