Loss of adherens junctions is a hallmark of EMT, and TGFβ can induce E-cadherin loss by transcriptional repression (that requires long-term sustained signaling) of the E-cadherin (CDH1) gene and lysosomal degradation of cell surface E-cadherin, a process contributing to breast cancer metastasis [36]. The gene discussed is CDH1; the disease is breast cancer.