The mitogen-inducible gene 6 (MIG6) is a negative regulator of the EGF receptor, which is under the negative control of miR-200 in epithelial cells; when TGFβ induces EMT in lung and pancreatic cancer cells, it represses the expression of miR-200, indirectly resulting in the stabilization of MIG6 and a relative inhibition of EGF receptor [62]. Here, TGFB1 is linked to familial pancreatic carcinoma.