ZEB1 and ZEB2 are transcriptionally regulated by Fos-related antigen 1 (Fra-1), which is a member of the Fos family of basic leucine zipper domain proteins, dimerized with c-Jun to form the activator protein 1 (AP-1), and negatively correlated with the prognosis of breast cancer patients [88]. This evidence concerns the gene FOSL1 and breast carcinoma.