TGFB1 and breast carcinoma: In the target bone tissue, breast carcinoma cells that extravasate from the bone marrow fenestrated vessels, respond to stromal TGFβ and turn on the expression of IL-11 and Parathyroid Hormone-Related Protein, which act on osteoblasts and mobilize the secretion of the cytokine RANKL, which finally leads to osteoclast differentiation and activity [143].