TGFB1 and cancer: The expression of specific myosin isoforms during EMT is thought to contribute to differential patterns of cancer cell motility; accordingly, an ameboid movement can be induced in melanoma cells in response to TGFβ signaling via transcriptional cooperation of Smad2 and Cbp/p300-interacting transactivator 1 (CITED1) causing the expression of specific myosin light chain isoforms [59].