TGFB1 and cancer: TGFβ can additionally induce proteasomal degradation of two alternative guanine exchange factors of Rho GTPases during EMT, the leukemia-associated Rho guanine nucleotide exchange factor (LARG), and GEF-H1, a necessary mechanism for the adaptation of mesenchymal cells to integrin signaling mediated by ECM changes associated with cancer cell invasiveness [53].