An exceptional case that illustrates the diversity of actions TGFβ can take during metastasis is exemplified by studies of the knockout of the TGFβ type II receptor gene in breast carcinomas, which become refractory to TGFβ responses, yet, they oversecrete TGFβ and chemokines of the CXCL family (SDF-1, CXCL5), which act as chemo-attractants and recruit myeloid cells to the tumor [146]. Here, TGFB1 is linked to neoplasm.