Functional studies on miR-708 in renal cell carcinoma (RCC) showed that miR-708 was identified as target for survivin, Zinc finger E-box-binding homeobox 2 (ZEB2) and B lymphoma Mo-MLV insertion region 1 homolog (BMI1), and expression level of miR-708 was widely reduced in RCC patients [38]. Here, ZEB2 is linked to hereditary clear cell renal cell carcinoma.