Also, molecular classifiers of outcome include loss of heterozygosity (LOH) of 1p19q, telomerase reverse transcriptase (TERT), alpha-thalassemia/mental retardation syndrome X-linked (ATRX), or isocitrate dehydrogenase (IDH)-1 or -2 mutations [56]. This evidence concerns the gene ATRX and alpha thalassemia spectrum.