Other biological functions of TGase 2 have been discussed in reviews [16,17]; these include nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) activation through inhibition of nuclear factor of κ light polypeptide gene enhancer in B-cells inhibitor α (I-κBα) [18], hypoxia-inducible factor 1-α (HIF-1α) activation through inhibition of von Hippel-Lindau tumor suppressor (VHL) [19], and suppression of cancer cell apoptosis through inhibition of p53 [5,17]. This evidence concerns the gene VHL and cancer.