A single treatment with streptonigrin reduced CAKI-1 tumor growth in a dose-dependent manner over six weeks, as shown in Figure 5A. After 43 days, tumors in streptonigrin-treated mice were approximately 10-times smaller than those in control mice, see Figure 5A. Tumors were collected at the end of the study and immunohistochemical staining for TGase 2, p53, and Ki67 was performed, see Figure 5B–D. This evidence concerns the gene TGM2 and neoplasm.