IFNG and systemic lupus erythematosus: Furthermore, given the evidence of a positive role of IFN-γ in Bcl-6 expression and Tfh accumulation in lupus development [47], it is reasonable to speculate that apart from a Th1-dependent IgG response [48, 49], P. yoelii 17XNL elicited IFN-γ response might has additional effect on the differentiation of the Tfh lineage, thus favoring protective humoral immunity to the infection.