These data, together with the observation of reduced serum IFN-γ in Nedd8ΔT mice compared to Nedd8fl/fl controls at day 5 p.i. (Fig 4A), clearly demonstrate that disruption of neddylation in T cells impairs IFN-γ-mediated proinflammatory response during the early phase of P. yoelii 17XNL infection. Here, IFNG is linked to infection.