SREBF1 and urinary bladder cancer: Hence, the anti-tumorigenic effects of DR and dwarfism [9,29] may involve repression of Fgfr3. Furthermore, in-vitro studies with bladder cancer cell lines confirmed Fgfr3 as a direct activator of lipogenesis via Srebf1 [99–101], which itself becomes hypermethylated and repressed under DR [49,102,103].