Studies of AD also indicate that TOMM40 variants are unlikely to have a major effect on AD (Yu et al., 2007), although the role of TOMM40‐APOE haplotypes in AD is also acknowledged (Jazwinski et al., 2010; Lescai et al., 2011; Roses et al., 2010). The gene discussed is APOE; the disease is Alzheimer disease.