Of the many pathways that we found perturbed during myogenesis in FSHD (Supplementary Material, Tables S2–7), we decided to focus on the ERRα/PGC1α pathway, of interest considering the sensitivity of FSHD cells to oxidative stress and know mitochondrial dysfunction (21,45,46). The gene discussed is PPARGC1A; the disease is facioscapulohumeral muscular dystrophy.