Eight (89%) of studies included neonatal sepsis with PPROM and healthy neonates with PPROM, and only one study included neonatal sepsis with PROM and healthy neonates with PROM.[8] Only one study did not report patient's age.[11] Patients’ age, number of patients, assay method, specimen, cut-off value, type of sepsis sensitivity, specificity, TP, FP, FN, and TN of IL-6 in each trial are shown in Table 1. This evidence concerns the gene IL6 and preterm premature rupture of the membranes.