Interleukin-6 (IL-6) is a pleiotropic cytokine expressed by different cells in response to infections.[22] Recently, IL-6 has been investigated for its validity in diagnosing neonatal sepsis.[23] However, there are no large-scale multicenter studies or meta-analyses on IL-6 for the diagnosis of neonatal sepsis with PROM. Here, IL6 is linked to infection.