Routine laboratory tests, such as C-reactive protein (CRP) and procalcitonin (PCT), which mediated the host response to bacterial infection and released in the neonatal blood, have low sensitivity.[18,19] In addition, evidence indicates that antibiotic prophylaxis applied in 42% of the deliveries showed no beneficial effect on the incidence of neonatal sepsis and even made early diagnosis of neonatal sepsis more difficult.[20,21] Therefore, early detection of neonatal sepsis with PROM should be developed to reduce the inadvertent use of antibiotics, cost of treatment, and overtreatment. The gene discussed is CRP; the disease is bacterial infectious disease.