Excluding the study that showed high concerns in reference standard,[9] the pooled sensitivity, specificity, and AUC of IL-6 for neonatal sepsis with PROM were 0.85 (95% CI: 0.78–0.90), 0.87 (95% CI: 0.84–0.90), and 0.9410, respectively, which showed high stability. The gene discussed is IL6; the disease is Neonatal sepsis.