PPARA and psychiatric disorder: In recent years, interest in the physiological role of PPARα in the CNS has been growing, as these receptors might be involved in the neuropathogenesis, and therapy, of neurological and psychiatric disorders.13, 46, 47 PPARα displays a distinct pattern of expression in the CNS in neurons and glial cells,48 but the precise physiological role of PPARα in neurons is still unclear.