PPARα are also expressed by macrophages, where decrease inflammation‐evoked activation and induce a decrease in the expression of NOS‐2 and proinflammatory cytokines.50 Our result is consistent with the anti‐inflammatory and neuroprotective properties of N‐acylethanolamines (NAEs), endogenous PPARs ligands, or fenofibrate in Parkinson's and Alzheimer's disease, epilepsy, and psychiatric disorders (ie, schizophrenia and depression).13, 47, 51, 52. Here, PPARA is linked to early-onset autosomal dominant Alzheimer disease.