TGFBR2 and type 2 diabetes mellitus: It carries Smad 4 to the activated TGFBR2‐complex and promotes the phosphorylation of Smad 2/3, which subsequently induces the biological functions of the Smad network.20 Of particular interest to this study is the relevance of TGFBR2 and TGFBRAP1 polymorphisms to the genetic susceptibility of T2DM.