Meanwhile, the secretory vesicle (v) SNAREs (VAMP2) interact with the target membrane (t) SNARE proteins (STX‐1 and SNAP25) to form a stable heterotrimeric complex to facilitate membrane fusion,44, 45, 46 and their deficiency is responsible, in part, for the impaired insulin secretion in both human T2DM and animal models of T2DM.5, 47 Consistent with these findings, SNARE proteins as well as MafA, MafB and PDX‐1 were found to be significantly decreased in db/db mice. Here, PDX1 is linked to type 2 diabetes mellitus.