Recent studies have shown that FGF21 is also abundant in the pancreas36 and plays an anti‐inflammatory role in pancreatitis in mice.37 Furthermore, exogenous administration of FGF21 can improve islet transplant success as well as protect islets from glucolipotoxicity and cytokine‐induced apoptosis.23, 25 A recent study has suggested that FGF21 is highly expressed in exocrine pancreas and functions as an exocrine pancreas secretagogue,38 which is not consistent with our findings that the majority of pancreatic FGF21 is synthesized in the islets of C57/BL6 mice at the basal state. The gene discussed is FGF21; the disease is pancreatitis.