It is also reported that CREB and phosphorylated CREB (p‐CREB) have been shown to be consistently over‐expressed in breast cancer tissues.29, 30, 31, 32 CREB regulates a number of critical genes involved in cellular proliferation, anti‐apoptosis and metastasis of breast cancer.33, 34 These include b‐cell lymphoma 2 (Bcl‐2), vascular endothelial growth factor and type IV collagenase matrix metalloproteinase 2. This evidence concerns the gene MMP2 and breast cancer.