The FL-MAVS down-regulation was highly specific, as the levels of mini-MAVS, a truncated isoform that is unable to trigger IFN induction (Brubaker et al., 2014), other signaling molecules (RIG-I, TBK1, IKKε, TRAF2, β-TrCP), control mitochondrial (Fis1, COXIV), and peroxisomal (PMP70) proteins were only affected at a high multiplicity of infection (MOI) of 10 and only at the latest time point examined (12 hr post infection) (Figure 2B). This evidence concerns the gene IKBKE and infection.