In contrast, infection of the human origin HT-29 cells with the human RV Wa strain, but not the simian RRV strain, was capable of degrading human MAVS (Figure 2C, middle panel; Figure 2—figure supplement 1B, lower panel), highlighting a unique pattern of virus-strain host-species co-segregation with the MAVS degradation phenotype. Here, MAVS is linked to infection.