NFE2L2 and ischemia: 2011; Zhang et al. 2014). Guo et al. (2014) also demonstrated that Nrf2 might play a pivotal role in activating the endogenous defense system and thus it protects the neural cell from an ischemic brain injury. Numerous studies have shown the neuroprotective effects of resveratrol in various animal models via modulating multiple signalling pathways (Shin et al. 2012; Bastianetto et al. 2015). However, the neuroprotective potential of numerous phyto-components is demonstrated by positively modulating Nrf2/HO-1 signalling pathway (Ping et al. 2010; Peng et al. 2013) in models of ischemia.