Increased cell surface heterophilic carbohydrate antigen expression can be targeted by macrophages, such as Thomsen‐Friedenreich antigen (Galß1‐3GalNAcα‐), a common feature in malignant and pre‐malignant epithelia.27 Hence, it is likely that CD47‐SIRPα signaling may also override the activating signals delivered to macrophages by cancer antigens. The gene discussed is CD47; the disease is cancer.