rs12897 is a common variant (MAF 0.41) showing a protective association with CAD; OR 0.96 (95% C.I. 0.95, 0.97) (p = 1.9 × 10−10), this SNP is an eQTL for the protein coding gene Fibronectin type III domain containing 3B (FNDC3B) (39) occurring in the 3′ UTR region of the mRNA likely affecting post-transcriptional regulation of gene expression. This evidence concerns the gene FNDC3B and coronary artery disorder.