CDKN2B-AS1 and coronary artery disorder: Together, linear ANRIL confers overproliferation, and circular ANRIL protects from overproliferation, suggesting that the genotype of Chr9p21 is important to determine the balance of linear and circular ANRIL levels in SMCs and macrophages, and that a dominance of linear ANRIL in this ratio, even when small, over decades skews for CAD (36) (Figure 1B).