We have previously shown in a large series of patients (MGUS: n = 10; MM at diagnosis: n = 70; MM in remission: n = 52; MM in relapse: n = 24) that BM MM Vγ9Vδ2 T cells are unable to properly react to pAgs stimulation in terms of proliferation, CD107 expression and IFN-γ production. This evidence concerns the gene IFNG and Miyoshi myopathy.