Vγ9Vδ2 T cells are endowed with peculiar functional properties which make them very good candidates for immunotherapy: they do not require MHC restriction and co-stimulation; they produce pro-inflammatory cytokines (IFN-γ and TNF-α); they recognize antigens shared by a variety of stressed and tumor cells; they behave as professional antigen-presenting cells (21); they can provide help to B cells to produce antibodies (22); and they can induce DC maturation boosting αβ T cell priming and MHC-restricted antigen-specific T-cell responses (23). This evidence concerns the gene HLA-C and neoplasm.